This iconic Southampton estate sits on the most esteemed Rice block. This rare opportunity features an almost half-acre premier corner lot (19,800 sq. ft. per HCAD) in highly desirable Southampton Place. Beautiful frontage along Rice Blvd., directly across from Rice University, and expansive footage with garage access along Shepherd Dr. Stunning mature oak trees in the front and back yards await your vision for luxurious new construction with ample room for a pool, or the potential to remodel the existing 3200+ sqft home. Residents benefit from private security patrols and an active Civic Club. This highly sought-after residential neighborhood offers close proximity to the Texas Medical Center, Museum District, Hermann Park, and popular Rice Village. Enjoy the local eateries and shopping as well.